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In a new study published in the journal Frontiers in Medicine, researchers from the Johns Hopkins Bloomberg School of Public Health, with colleagues at the California Center for Functional Medicine and Focus Health, surveyed the power of 14 plant-based extracts to kill Borrelia burgdorferi, the bacterium that causes Lyme diseases, compared to the currently used…
Differences in skin odors are a potential major player in whether you’re eaten alive by mosquitoes or passed up for a more enticing snack The most enticing scents to mosquitoes came from people with higher levels of carboxylic acids, which are produced in sebum, an oily compound that helps keep skin moisturized Compared to the…
Protein kinase B (AKT), is a pivotal component of pathways associated with cell survival, metabolism, invasion and metastasis. AKT mediates anti‑apoptotic and proliferative signaling in response to essential cytokines. Tumor necrosis factor receptor‑associated factor (TRAF)6, an E3 ubiquitin ligase, has been shown to ubiquitylate, as well as activate AKT. The present study used computational methods…
Unlike diseases that impair the body in a myriad of physical ways, dementia can rob mental faculties and identity, as patients struggle to remember memories from previous days. As the disease progresses, victims may also forget friends or relatives and the functional skills to perform a daily routine. The most common form of dementia, Alzheimer’s…
Lyme disease is a tick-borne multisystemic disease caused by Borrelia burgdorferi. Administering antibiotics is the primary treatment for this disease; however, relapse often occurs when antibiotic treatment is discontinued. The reason for relapse remains unknown, but recent studies suggested the possibilities of the presence of antibiotic resistant Borrelia persister cells and biofilms. In this study, we evaluated the…
Computational modeling was performed to predict that a series of Cinchona alkaloids can effectively bind to the RING domain of TRAF6, leading to disruption of its native binding with the Ubc13 protein, which is critical for initiating downstream events of AKT and TAK1 activations. Both in vitro and in vivo experiments distinctly demonstrated that these Cinchona alkaloids could induce early apoptosis and…
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