In vitro and in vivo cancer cell triggered by competitive binding of Cinchona alkaloids
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In vitro and in vivo cancer cell triggered by competitive binding of Cinchona alkaloids

Bybeyouintegrativehealth

Computational modeling was performed to predict that a series of Cinchona alkaloids can effectively bind to the RING domain of TRAF6, leading to disruption of its native binding with the Ubc13 protein, which is critical for initiating downstream events of AKT and TAK1 activations. Both in vitro and in vivo experiments distinctly demonstrated that these Cinchona alkaloids could induce early apoptosis and…

Suppression of Tumor Cell Proliferation By Quinine Via The Inhibition of The Tumor Necrosis Factor Receptor Associated Factor 6‑AKT Interaction
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Suppression of Tumor Cell Proliferation By Quinine Via The Inhibition of The Tumor Necrosis Factor Receptor Associated Factor 6‑AKT Interaction

Bybeyouintegrativehealth

Protein kinase B (AKT), is a pivotal component of pathways associated with cell survival, metabolism, invasion and metastasis. AKT mediates anti‑apoptotic and proliferative signaling in response to essential cytokines. Tumor necrosis factor receptor‑associated factor (TRAF)6, an E3 ubiquitin ligase, has been shown to ubiquitylate, as well as activate AKT. The present study used computational methods…