Immune – Cell Support #2

Andrographis (Andrographis paniculata), has been used for centuries in China and India is considered anti-spirochetal, and is believed to enhance immune function, protect heart muscle, act as an anti-inflammatory (for arthritic symptoms) and enhance and protect liver function.

Andrographolide (AGP) is a phytochemical which has anti-cancer properties and many studies have reported its wide use as a weapon to fight against cancer (Mishra et al., 2015). The natural source of AGP is the plant, Andrographis paniculata (Burm. f.) of the family Acanthaceae. The extract of A. paniculata, i.e., AGP has several biological activities, such as antioxidant (Xu et al., 2019), antiviral, antibacterial (Wiart et al., 2005), anti-inflammatory (Abu-Ghefreh et al., 2009), antipyretic (Madav et al., 1995), anti-thrombotic, hepatoprotective (Pan et al., 2017), and most importantly, it has anti-cancer properties (Farooqi et al., 2020). AGP also acts as an immunomodulator or immunostimulant (Churiyah, 2015).

Studies related to Lyme

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050641/

https://www.einnews.com/pr_news/555293457/andrographis-paniculata-is-a-promising-antimicrobial-agent-study-shows

https://www.nature.com/articles/s41598-021-87283-y

https://pubmed.ncbi.nlm.nih.gov/14641821/

https://www.spandidos-publications.com/10.3892/ol.2021.12784

Studies related to cancer
https://www.frontiersin.org/articles/10.3389/fphar.2021.731492/full#:~:text=Andrographolide%20(AGP)%20is%20a%20phytochemical,of%20the%20family%20Acanthaceae.
https://pubmed.ncbi.nlm.nih.gov/18471507/
https://pubmed.ncbi.nlm.nih.gov/32296018/
https://pubmed.ncbi.nlm.nih.gov/29200829/

Dyer’s Broom
The genus Genista L. (Leguminosae), whose taxonomy has been in dispute since the genus was grouped by Linné in 1753, consists of 87 species, predominantly distributed in the Mediterranean area. Among these species, 19 grow in Italy [1]. The genus belongs to the Genisteae tribe that includes spiny and unarmed shrubs or perennial herbs, woody at the base, characterized by generally yellow flowers with the filaments of the ten stamens grown together, that is monadelphous [2]. Genista is known to contain flavonoids, as well as lupine-type quinolizidine alkaloids [3]. Many species show interesting biological properties, such as antihyperglycemic, antiinflammatory, antiulcer, spasmolytic, antioxidant, estrogenic and cytotoxic activity against different human cancer cell lines [4-10].

The substance is isolated from the plant dyer’s greenweed or dyer’s broom (Genista tinctoria), from whose Latin name comes the name of the substance. Genistein is also found in soybeans (Glycine max), lupine (Lupinus), broad beans or fava bean (Vicia faba), Psoralea, kudzu (Japanese arrowroot or Chinese arrowroot), coffee.

Genista tinctoria was found to be a potent agent in both prophylaxis and treatment of cancer as well as other chronic diseases. At the molecular level, genista tinctoria acts via an estrogen receptor-mediated mechanism and also inhibits the activity of Adenosine triphosphate (ATP) utilizing enzymes such as: tyrosine-specific protein kinases, topoisomerase II and enzymes involved in phosphatidylinositol turnover. Genista tinctoria was found to induce apoptosis and differentiation in cancer cells, inhibit cell proliferation, modulate cell cycling, exert antioxidant effects, inhibit angiogenesis, and suppress osteoclast and lymphocyte functions.

Studies related to Lyme & Dyers Broom

http://herbs-treatandtaste.blogspot.com/2012/07/dyers-broom-dyers-greenwood-possible.html
https://agris.fao.org/agris-search/search.do?recordID=US201302518248
https://pubmed.ncbi.nlm.nih.gov/15612629/

Studies showing promising results of the usage of Dyers Broom for Cancer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495920/
https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/genista-tinctoria
https://www.academia.edu/13268584/Genista_sessilifolia_DC_and_Genista_tinctoria_L_inhibit_UV_light_and_nitric_oxide_induced_DNA_damage_and_human_melanoma_cell_growth
https://www.oncology-central.com/genistein-mechanisms-of-action-in-colorectal-cancer/
https://journals.sagepub.com/doi/pdf/10.1177/1934578X1000500731